[Medical Informatics](/majors/health-care-professions/medical-illustration-informatics/medical-informatics/) degree programs vary widely in price and payoff across the country. The best values balance affordable tuition against strong post-graduation earnings.
To produce this 2027 ranking, College Factual evaluated 2 schools on the balance of cost and outcomes for medical informatics students.
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Below are the schools that deliver the strongest value in medical informatics, balancing cost against outcomes.
For return on investment in medical informatics, no school beat University Of South Carolina Upstate this year. University Of South Carolina Upstate is a moderately-sized public school located in the suburb of Spartanburg. Students from in state pay about $11,588 in tuition and fees, with out-of-state students paying around $23,090. Medical Informatics graduates carry a median of $30,289 in student loans. Medical Informatics graduates of University Of South Carolina Upstate earn a median of $39,473 early in their careers. Set against $30,289 in median debt, that is a healthy payoff. Roughly 67% of applicants are accepted.
The strong cost-to-outcome balance at University Of South Carolina Columbia earned it the #2 place for medical informatics. Located in the city of Columbia, University Of South Carolina Columbia is a very large public university. Expect in-state tuition and fees of around $12,688, compared with $36,298 for out-of-state students. Typical student debt for medical informatics graduates is $24,537. Medical Informatics graduates of University Of South Carolina Columbia earn a median of $53,623 early in their careers. That is a strong return on a $24,537 median debt. The acceptance rate is 60%.
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Notes and References
The ranking above is published by College Factual (MF_RANKING_2025), 2027 edition. Schools are scored on the balance of cost (tuition and student debt) against student outcomes (post-graduation earnings) — a measure of return on investment, drawn primarily from the U.S. Department of Education (IPEDS and College Scorecard).
Ranking method: College Major Best Value · 2 schools evaluated.
*Averages shown above reflect the top 2 ranked schools only.
- The Integrated Postsecondary Education Data System (IPEDS) from the National Center for Education Statistics (NCES), a branch of the U.S. Department of Education (DOE), serves as the core of our data about colleges.
- Some other college data, including much of the graduate earnings data, comes from the U.S. Department of Education’s (College Scorecard).
More about our data sources and methodologies.
