[Biomathematics & Bioinformatics](/majors/biological-biomedical-sciences/biomathematics-bioinformatics-computational-biology/) degree programs vary widely in price and payoff across the country. A high-value program keeps cost low while graduates go on to earn well.
College Factual analyzed 8 schools to build this 2027 ranking of the best value biomathematics & bioinformatics schools.
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Below are the schools that deliver the strongest value in biomathematics & bioinformatics, balancing cost against outcomes.
University Of Illinois At Chicago tops our 2027 list of the best value biomathematics & bioinformatics schools in the Great Lakes Region. Located in the city of Chicago, University Of Illinois At Chicago is a very large public university. Students from in state pay about $15,949 in tuition and fees, compared with $32,009 for out-of-state students. Typical student debt for biomathematics & bioinformatics graduates is $20,115. Soon after graduation, biomathematics & bioinformatics degree recipients from University Of Illinois At Chicago generally make around $61,829. That is a strong return on a $20,115 median debt. The acceptance rate is 77%.
The strong cost-to-outcome balance at University Of Michigan Ann Arbor earned it the #2 place for biomathematics & bioinformatics. Located in the city of Ann Arbor, University Of Michigan Ann Arbor is a very large public university. The average in-state cost of tuition and fees is $18,848, with out-of-state students paying around $63,081. Students borrow a median of $19,137 to complete the biomathematics & bioinformatics program here. Soon after graduation, biomathematics & bioinformatics degree recipients from University Of Michigan Ann Arbor generally make around $71,336. That is a strong return on a $19,137 median debt. University Of Michigan Ann Arbor admits about 16% of applicants.
Students looking for strong value in biomathematics & bioinformatics will find it at Indiana University Purdue University Indianapolis, which ranked #3. Indiana University Purdue University Indianapolis is a very large public school located in the city of Indianapolis. The average in-state cost of tuition and fees is $10,762, compared with $34,891 for out-of-state students. Students borrow a median of $23,146 to complete the biomathematics & bioinformatics program here. Early-career biomathematics & bioinformatics graduates make about $56,930. Weighed against typical debt, the earnings make a compelling case for value. Indiana University Purdue University Indianapolis admits about 76% of applicants.
University Of Chicago came in at #4 on our 2027 list of the best value biomathematics & bioinformatics schools. University Of Chicago is a very large private not-for-profit school located in the city of Chicago. The average in-state cost of tuition and fees is $69,324. Typical student debt for biomathematics & bioinformatics graduates is $15,854. Soon after graduation, biomathematics & bioinformatics degree recipients from University Of Chicago generally make around $99,193. Weighed against typical debt, the earnings make a compelling case for value. The acceptance rate is 4%.
Western Michigan University is a great value for students pursuing a degree in biomathematics & bioinformatics, landing the #5 spot this year. Western Michigan University is a large public school located in the city of Kalamazoo. Expect in-state tuition and fees of around $15,987, with out-of-state students paying around $19,952. Biomathematics & Bioinformatics graduates carry a median of $27,981 in student loans. Soon after graduation, biomathematics & bioinformatics degree recipients from Western Michigan University generally make around $48,966. Set against $27,981 in median debt, that is a healthy payoff. Roughly 85% of applicants are accepted.
Grand Valley State University earned the #6 position for value in biomathematics & bioinformatics this year. Grand Valley State University is a very large public school located in the town of Allendale. In-state tuition and fees average $15,502, compared with $21,894 for out-of-state students. Typical student debt for biomathematics & bioinformatics graduates is $26,378. Biomathematics & Bioinformatics graduates of Grand Valley State University earn a median of $74,986 early in their careers. Weighed against typical debt, the earnings make a compelling case for value. Grand Valley State University admits about 83% of applicants.
Loyola University Chicago placed #7 among the best values for biomathematics & bioinformatics. Set in the city of Chicago, Loyola University Chicago is a large private not-for-profit institution. Expect in-state tuition and fees of around $53,710. Biomathematics & Bioinformatics graduates carry a median of $23,521 in student loans. Soon after graduation, biomathematics & bioinformatics degree recipients from Loyola University Chicago generally make around $58,568. Set against $23,521 in median debt, that is a healthy payoff. Roughly 82% of applicants are accepted.
Case Western Reserve University earned the #8 position for value in biomathematics & bioinformatics this year. Case Western Reserve University is a large private not-for-profit school located in the city of Cleveland. The average in-state cost of tuition and fees is $66,608. Biomathematics & Bioinformatics graduates carry a median of $25,106 in student loans. Biomathematics & Bioinformatics graduates of Case Western Reserve University earn a median of $74,459 early in their careers. Weighed against typical debt, the earnings make a compelling case for value. Case Western Reserve University admits about 36% of applicants.
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Notes and References
The ranking above is published by College Factual (MF_RANKING_2025), 2027 edition. Schools are scored on the balance of cost (tuition and student debt) against student outcomes (post-graduation earnings) — a measure of return on investment, drawn primarily from the U.S. Department of Education (IPEDS and College Scorecard).
Ranking method: College Major Best Value · 8 schools evaluated.
*Averages shown above reflect the top 8 ranked schools only.
- The Integrated Postsecondary Education Data System (IPEDS) from the National Center for Education Statistics (NCES), a branch of the U.S. Department of Education (DOE), serves as the core of our data about colleges.
- Some other college data, including much of the graduate earnings data, comes from the U.S. Department of Education’s (College Scorecard).
More about our data sources and methodologies.
